SORBS2

Across TCGA patient cohorts, SORBS2 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,137 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SORBS2-associated proteins across cancer lineages are SORBS2_S157, SORBS2_S259, and SORBS2_S302. Each is linked with SORBS2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SORBS2-to-partner and partner-to-SORBS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SORBS2 versus SORBS2_S157 in GBM, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS2→partner) and Y-score (partner→SORBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SORBS2_S157 →	+0.788	+0.810	<.001	<.001	3	7
LSCC	SORBS2_S259 →	+0.717	+0.698	<.001	<.001	3	7
HNSC	SORBS2_S302 →	+0.780	+0.924	<.001	<.001	3	7
HNSC	DDAH1 →	+0.516	+0.697	<.001	<.001	3	7
BRCA	RGN →	+0.706	+1.039	<.001	<.001	3	6
CCRCC	SORBS2_S1018 →	+1.100	+1.390	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,137 associations by consensus.

SORBS2 vs SORBS2_S157 — GBM

Explore this scatter interactively →