SORBS2

Across TCGA pan-cancer cohorts, SORBS2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SORBS2’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SORBS2 RNA is repressed in tumor relative to normal tissue. In most cancer types SORBS2 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and KICH are the cancer types where SORBS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SORBS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−4.287	<.001	11	view →
THCA	Male	III,IV	−3.784	<.001	11	view →
KICH	Male	IV	−2.836	<.001	11	view →
HNSC	Male	All	−1.897	<.001	11	view →
COAD	Male	II,III,IV	−1.549	<.001	10	view →
LUSC	Female	II,III,IV	−2.411	<.001	9	view →
STAD	All	II,III,IV	−1.391	<.001	8	view →
BRCA	All	III,IV	−1.468	<.001	6	view →
LUAD	Female	II,III,IV	−0.923	.006	5	view →
KIRC	Male	All	+0.484	<.001	3	view →
READ	All	All	−2.106	.001	2	view →
ESCA	All	All	−1.007	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SORBS2–BLCA

Open the BLCA breakdown →