SORBS2

Across TCGA patient cohorts, SORBS2 mutation is significantly associated with the RNA expression of many other genes, with 7,729 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORBS2-associated genes across cancer lineages are GMEB1, GEMIN2, and CLSPN. Each is linked with SORBS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SORBS2-to-partner and partner-to-SORBS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMEB1 grouped by SORBS2-low versus SORBS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS2→partner) and Y-score (partner→SORBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GMEB1 →	+0.396	+3.183	<.001	<.001	3	4
UCEC	GEMIN2 →	+0.391	+2.676	<.001	<.001	3	4
UCEC	CLSPN →	+0.663	+1.436	<.001	<.001	3	4
UCEC	HELLS →	+0.566	+1.457	<.001	<.001	3	4
UCEC	DLGAP5 →	+0.710	+1.565	<.001	<.001	3	4
UCEC	PARP2 →	+0.472	+1.807	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,729 associations by consensus.

GMEB1 by SORBS2 expression — COAD

Explore this box plot interactively →