SOD2

Across TCGA patient cohorts, SOD2 mutation is significantly associated with the RNA expression of many other genes, with 207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOD2-associated genes across cancer lineages are IGHD5OR15-5B, RNU6-1298P, and RNU6-355P. Each is linked with SOD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOD2-to-partner and partner-to-SOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD5OR15-5B grouped by SOD2-low versus SOD2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOD2→partner) and Y-score (partner→SOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGHD5OR15-5B →	+0.962	+7.954	<.001	.008	3	1
HNSC	RNU6-1298P →	+0.358	+7.954	<.001	.008	3	1
HNSC	RNU6-355P →	+0.348	+7.954	<.001	.008	3	1
COAD	GOLGA8O →	+0.094	+3.809	<.001	.009	3	1
COAD	OR2W2P →	+0.071	+4.537	<.001	.006	3	1
COAD	CICP18 →	+0.023	+4.602	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 207 associations by consensus.

IGHD5OR15-5B by SOD2 expression — HNSC

Explore this box plot interactively →