SOD2

Across TCGA pan-cancer cohorts, SOD2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SOD2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SOD2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SOD2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where SOD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.548	<.001	12	view →
KICH	All	II,III,IV	−1.258	<.001	8	view →
KIRP	Male	All	+1.231	<.001	7	view →
BRCA	All	III,IV	−1.320	<.001	6	view →
STAD	All	All	+0.771	.004	5	view →
BLCA	All	All	−0.790	.017	4	view →
READ	Male	All	+1.616	.043	2	view →
ESCA	All	All	+1.088	.033	2	view →
LUSC	All	All	−0.447	.016	2	view →
THCA	All	All	−0.257	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SOD2–KIRC

Open the KIRC breakdown →