SNX6

Across TCGA patient cohorts, SNX6 mutation is significantly associated with the RNA expression of many other genes, with 2,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX6-associated genes across cancer lineages are MIR6881, IGLJ6, and MIR6857. Each is linked with SNX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX6-to-partner and partner-to-SNX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6881 grouped by SNX6-low versus SNX6-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX6→partner) and Y-score (partner→SNX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6881 →	+0.585	+4.800	<.001	.006	3	2
BRCA	IGLJ6 →	+0.790	+5.080	<.001	.001	3	2
UCEC	MIR6857 →	+0.304	+2.773	<.001	<.001	3	2
BLCA	POU5F1P2 →	+0.040	+4.314	<.001	.009	3	2
BRCA	MRPS17P5 →	+0.353	+6.426	<.001	<.001	3	1
UCEC	BTBD10 →	+0.635	+3.502	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,739 associations by consensus.

MIR6881 by SNX6 expression — BRCA

Explore this box plot interactively →