SNX6

Across TCGA pan-cancer cohorts, SNX6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SNX6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNX6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNX6 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where SNX6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNX6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+1.013	<.001	12	view →
BLCA	All	All	+0.541	<.001	11	view →
LIHC	All	II,III,IV	+0.744	<.001	7	view →
CHOL	Male	All	+1.959	<.001	5	view →
KICH	Female	All	−0.980	<.001	5	view →
LUAD	Male	All	+0.539	<.001	5	view →
THCA	All	All	−0.276	.003	5	view →
ESCA	All	All	+0.611	.005	4	view →
LUSC	Male	All	+0.488	<.001	4	view →
COAD	All	All	−0.428	.002	4	view →
KIRP	Female	II,III,IV	+0.870	.023	3	view →
READ	Female	All	−0.944	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SNX6–HNSC

Open the HNSC breakdown →