SNX6

Across TCGA pan-cancer cohorts, SNX6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SNX6 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SNX6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNX6 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

LIHC, ACC, and KICH are the cancer types where SNX6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.702	0.846	<.001	74	view →
ACC	DFS	Median	All	0.384	0.770	<.001	68	view →
KICH	DFS	Quartile	II,III,IV	0.362	1.000	<.001	59	view →
HNSC	OS	Quartile	All	0.266	0.629	.001	54	view →
SCLC	OS	Median	II,III,IV	0.443	0.978	.012	39	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
KIRC	DFS	Median	All	0.762	0.494	<.001	34	view →
PAAD	DFS	Quartile	All	0.135	0.425	<.001	31	view →
CESC	DFS	Quartile	All	0.397	0.706	.011	30	view →
SKCM	OS	Quartile	All	0.820	0.683	.003	30	view →
BLCA	OS	Quartile	II,III,IV	0.635	0.797	.004	29	view →
BRCA	DFS	Quartile	III,IV	0.886	0.695	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SNX6–LIHC (OS)

Open the LIHC breakdown →