SNX6

Across TCGA patient cohorts, SNX6 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX6-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and INPP4B. Each is linked with SNX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX6-to-partner and partner-to-SNX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SNX6-low versus SNX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX6→partner) and Y-score (partner→SNX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.711	+3.479	.004	.002	3	2
UCEC	EGFR_pY1068 →	-0.258	-2.222	.015	.011	3	1
UCEC	INPP4B →	-0.306	-2.999	.025	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.417	-1.687	.028	.044	3	1
UCEC	p62 Lck ligand →	+0.359	+3.009	.009	.019	3	1
UCEC	14-3-3_epsilon →	+0.086	+1.700	.040	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-7-cleavedD198 by SNX6 expression — UCEC

Explore this box plot interactively →