SNX6

Across TCGA cell cohorts, SNX6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,696 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SNX6-associated GO terms across cancer lineages are Monoubiquitinated protein deubiquitination, Actin filament fragmentation, and Golgi organization. Each is linked with SNX6 in more than 14 cancer types. Because this analysis shows association rather than direction, both SNX6-to-partner and partner-to-SNX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monoubiquitinated protein deubiquitination grouped by SNX6-low versus SNX6-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX6→partner) and Y-score (partner→SNX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Monoubiquitinated protein deubiquitination →	+0.132	+0.959	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Actin filament fragmentation →	+0.158	+1.034	.002	.005	3	14
STOMACH	Golgi organization →	+0.067	+0.793	.002	.001	3	12
BLOOD_Lymphoma	Protein catabolic process at synapse →	+0.158	+0.664	<.001	<.001	3	11
BLOOD_Lymphoma	Protein catabolic process at postsynapse →	+0.158	+0.664	<.001	<.001	3	11
BONE	Positive regulation of B cell differentiation →	+0.217	+0.985	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,696 associations by consensus.

Monoubiquitinated protein deubiquitination by SNX6 expression — SKIN

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