SNX6

Across TCGA cell cohorts, SNX6 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNX6-associated genes across cancer lineages are CCDC182, OR6S1, and LPAR3. Each is linked with SNX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX6-to-partner and partner-to-SNX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC182 grouped by SNX6-low versus SNX6-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX6→partner) and Y-score (partner→SNX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CCDC182 →	+0.033	+5.285	<.001	.003	3	1
STOMACH	OR6S1 →	+0.063	+5.285	<.001	.003	3	1
LARGE_INTESTINE	LPAR3 →	+1.532	+3.252	<.001	.009	3	1
LARGE_INTESTINE	OR4F21 →	+0.134	+2.878	<.001	.009	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+3.614	<.001	.006	3	1
LARGE_INTESTINE	SMIM33 →	+0.582	+3.426	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CCDC182 by SNX6 expression — STOMACH

Explore this box plot interactively →