SNX5

Across TCGA patient cohorts, SNX5 mutation is significantly associated with the RNA expression of many other genes, with 398 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX5-associated genes across cancer lineages are RPL36P1, RN7SL62P, and IGHVIV-44-1. Each is linked with SNX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNX5-to-partner and partner-to-SNX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL36P1 grouped by SNX5-low versus SNX5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX5→partner) and Y-score (partner→SNX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RPL36P1 →	+0.109	+4.906	.004	.003	3	2
CESC	RN7SL62P →	+0.152	+5.812	<.001	.003	3	2
CESC	IGHVIV-44-1 →	+0.248	+5.201	<.001	.007	3	2
UCEC	RPL7L1P4 →	+0.138	+2.407	<.001	.006	3	2
BRCA	AQP7P5 →	+0.039	+5.610	.006	.004	3	1
BRCA	MIR4803 →	+0.564	+6.382	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 398 associations by consensus.

RPL36P1 by SNX5 expression — LUSC

Explore this box plot interactively →