SNX4

Across TCGA patient cohorts, SNX4 mutation is significantly associated with the RNA expression of many other genes, with 2,323 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNX4-associated genes across cancer lineages are RNA5SP86, RNU6-281P, and RPS29P32. Each is linked with SNX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNX4-to-partner and partner-to-SNX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP86 grouped by SNX4-low versus SNX4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNX4→partner) and Y-score (partner→SNX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP86 →	+0.338	+4.912	<.001	.005	3	3
SKCM	RNU6-281P →	+0.373	+7.816	<.001	.008	3	2
HNSC	RPS29P32 →	+0.711	+4.505	<.001	.009	3	2
HNSC	TAAR8 →	+0.094	+6.020	<.001	<.001	3	2
HNSC	OR5F2P →	+0.240	+4.578	<.001	.008	3	2
HNSC	RNU6-508P →	+0.443	+6.357	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,323 associations by consensus.

RNA5SP86 by SNX4 expression — HNSC

Explore this box plot interactively →