SNX4

Across TCGA pan-cancer cohorts, SNX4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SNX4 data layer compared with 5 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SNX4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SNX4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

KIRC, LGG, and LUAD are the cancer types where SNX4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.730	0.521	<.001	182	view →
LGG	OS	Tertile	All	0.733	0.882	<.001	37	view →
LUAD	DFS	Median	IV	0.764	0.306	.010	24	view →
UCEC	DFS	Tertile	All	0.763	0.881	.001	22	view →
GBM	DFS	Tertile	All	0.463	0.181	.006	19	view →
LIHC	OS	Quartile	All	0.668	0.825	.003	19	view →
BRCA	DFS	Median	III,IV	0.922	0.831	.015	17	view →
SARC	DFS	Tertile	All	0.236	0.506	.005	17	view →
SKCM	DFS	Quartile	All	0.786	0.650	.005	14	view →
COAD	DFS	Median	IV	0.588	0.359	.006	12	view →
UCS	DFS	Tertile	IV	0.996	0.605	.036	12	view →
THYM	OS	Tertile	II,III,IV	1.000	0.578	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SNX4–KIRC (OS)

Open the KIRC breakdown →