SNTA1

Across TCGA cell cohorts, SNTA1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNTA1-associated genes across cancer lineages are OR6N1, OR2J1, and MAGEB1. Each is linked with SNTA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNTA1-to-partner and partner-to-SNTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6N1 grouped by SNTA1-low versus SNTA1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNTA1→partner) and Y-score (partner→SNTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OR6N1 →	+0.115	+4.870	.005	.001	3	1
LARGE_INTESTINE	OR2J1 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MAGEB1 →	+0.230	+3.878	<.001	.003	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR5V1 →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	INSRR →	+0.030	+3.658	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR6N1 by SNTA1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →