SNTA1

Across TCGA pan-cancer cohorts, SNTA1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SNTA1 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SNTA1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNTA1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where SNTA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.823	0.923	<.001	92	view →
LUAD	OS	Tertile	II,III,IV	0.779	0.624	.005	60	view →
HNSC	OS	Median	IV	0.659	0.798	.002	43	view →
KICH	OS	Quartile	III,IV	0.201	0.841	.002	33	view →
LUSC	OS	Median	III,IV	0.447	0.670	.007	22	view →
KIRC	DFS	Median	All	0.884	0.706	.001	19	view →
SKCM	OS	Median	All	0.278	0.399	.003	17	view →
COAD	DFS	Quartile	II,III,IV	0.678	0.812	.023	15	view →
READ	DFS	Median	III,IV	0.707	0.270	.034	12	view →
LIHC	DFS	Median	All	0.488	0.612	.019	12	view →
BRCA	OS	Tertile	All	0.940	0.900	.015	8	view →
THYM	DFS	Quartile	All	0.932	0.730	.017	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SNTA1–UCEC (OS)

Open the UCEC breakdown →