SNORD116-4

Across TCGA patient cohorts, SNORD116-4 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible SNORD116-4-associated genes across cancer lineages are DYNLL1P5, MTATP6P21, and RNU6-492P. Each is linked with SNORD116-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNORD116-4-to-partner and partner-to-SNORD116-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYNLL1P5 grouped by SNORD116-4-low versus SNORD116-4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNORD116-4→partner) and Y-score (partner→SNORD116-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	DYNLL1P5 →	+0.146	+5.337	.004	.006	3	2
SKCM	MTATP6P21 →	+0.214	+4.098	<.001	.001	3	2
LGG	RNU6-492P →	+0.283	+7.977	<.001	.007	3	1
LGG	RNU6-324P →	+0.398	+7.977	<.001	.007	3	1
LGG	MED15P1 →	+0.029	+7.977	<.001	.007	3	1
UCEC	MIR378E →	+0.443	+4.453	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

DYNLL1P5 by SNORD116-4 expression — LUSC

Explore this box plot interactively →