SNORD116-4

Across TCGA pan-cancer cohorts, SNORD116-4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SNORD116-4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SNORD116-4 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-4 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and STAD are the cancer types where SNORD116-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−1.676	<.001	8	view →
THCA	All	II,III,IV	−1.593	<.001	8	view →
STAD	All	All	−1.207	.001	7	view →
BRCA	All	III,IV	−0.992	<.001	6	view →
KICH	All	All	−0.915	.001	3	view →
LIHC	All	All	+0.363	.006	3	view →
CHOL	All	All	+1.427	.001	2	view →
KIRP	Male	All	−1.037	<.001	2	view →
UCEC	All	All	−0.878	.016	2	view →
LUAD	All	All	−0.433	.031	2	view →
LUSC	Female	III,IV	−1.950	.011	1	view →
READ	Female	All	−1.108	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SNORD116-4–BLCA

Open the BLCA breakdown →