SNORD116-4

Across TCGA pan-cancer cohorts, SNORD116-4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SNORD116-4 data layer compared with 2 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher SNORD116-4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD116-4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

MESO, LIHC, and KIRC are the cancer types where SNORD116-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Quartile	III,IV	0.188	0.442	.001	87	view →
LIHC	DFS	Tertile	All	0.454	0.590	.003	53	view →
KIRC	DFS	Median	All	0.740	0.513	<.001	52	view →
THCA	OS	Quartile	II,III,IV	0.555	1.000	.008	36	view →
UVM	DFS	Median	III,IV	0.489	0.835	.008	28	view →
ACC	DFS	Quartile	All	0.370	0.654	.006	25	view →
LUSC	DFS	Quartile	II,III,IV	0.466	0.651	.011	23	view →
HNSC	DFS	Tertile	IV	0.479	0.250	.005	19	view →
BLCA	DFS	Quartile	All	0.441	0.651	.017	14	view →
DLBC	DFS	Tertile	II,III,IV	0.537	1.000	.009	14	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	12	view →
LUAD	OS	Median	IV	0.337	0.756	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SNORD116-4–MESO (DFS)

Open the MESO breakdown →