Across TCGA patient cohorts, SNORD115-35 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SNORD115-35-associated genes across cancer lineages are HLTF-AS1, RNU4-14P, and NIFKP7. Each is linked with SNORD115-35 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNORD115-35-to-partner and partner-to-SNORD115-35 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNORD115-35→partner) and Y-score (partner→SNORD115-35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HLTF-AS1 →	+0.051	+4.199	<.001	.009	3	2
SKCM	RNU4-14P →	+0.430	+4.050	.001	.003	3	2
SKCM	NIFKP7 →	+0.083	+4.159	<.001	.002	3	1
SKCM	RNU6-496P →	+0.161	+4.993	<.001	.002	3	1
SKCM	HPYR1 →	+0.049	+4.408	.001	<.001	3	1
SKCM	OR8X1P →	+0.038	+5.080	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

SNORD115-35 survival (RNA) · tumor vs normal (RNA) · all SNORD115-35 data types