Across TCGA pan-cancer cohorts, SNORD115-35 RNA is linked to patient survival in 3 of 34 cancer types, making it the most broadly survival-associated SNORD115-35 data layer compared with 1 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SNORD115-35 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-35 expression acts as an unfavorable survival marker.

GBM, STAD, and PCPG are the cancer types where SNORD115-35 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.198	0.416	.031	18	view →
STAD	DFS	Tertile	II,III,IV	0.174	0.535	.043	9	view →
PCPG	OS	Tertile	All	0.539	0.954	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SNORD115-35 tumor-vs-normal RNA expression · all SNORD115-35 data types