SNORD114-21

Across TCGA patient cohorts, SNORD114-21 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNORD114-21-associated genes across cancer lineages are PDCL2P1, RNU4-58P, and RN7SKP224. Each is linked with SNORD114-21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNORD114-21-to-partner and partner-to-SNORD114-21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCL2P1 grouped by SNORD114-21-low versus SNORD114-21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNORD114-21→partner) and Y-score (partner→SNORD114-21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCL2P1 →	+0.327	+5.484	<.001	.005	3	2
UCEC	RNU4-58P →	+0.654	+5.133	<.001	.008	3	1
UCEC	RN7SKP224 →	+0.291	+5.133	.001	.008	3	1
UCEC	RNU6-1122P →	+1.012	+5.358	<.001	.006	3	1
UCEC	GSTA6P →	+0.212	+4.982	<.001	.009	3	1
UCEC	RN7SL191P →	+0.579	+5.081	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PDCL2P1 by SNORD114-21 expression — UCEC

Explore this box plot interactively →