SNORD114-21

Across TCGA pan-cancer cohorts, SNORD114-21 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated SNORD114-21 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SNORD114-21 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD114-21 expression acts as an unfavorable survival marker, although some lineages such as LAML show a favorable association.

BLCA, KICH, and CESC are the cancer types where SNORD114-21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.291	0.630	<.001	135	view →
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	90	view →
THCA	OS	Tertile	All	0.260	0.948	<.001	69	view →
STAD	OS	Tertile	IV	0.001	0.544	<.001	57	view →
SKCM	DFS	Tertile	All	0.203	0.625	<.001	51	view →
MESO	OS	Tertile	III,IV	0.215	0.594	.004	45	view →
CHOL	DFS	Tertile	All	0.045	0.486	.009	45	view →
OV	OS	Tertile	IV	0.028	0.759	.002	36	view →
LAML	DFS	Tertile	All	0.774	0.340	.011	18	view →
ACC	OS	Quartile	All	0.615	0.953	.001	18	view →
LIHC	DFS	Tertile	All	0.115	0.530	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SNORD114-21–BLCA (DFS)

Open the BLCA breakdown →