SNCB

Across TCGA patient cohorts, SNCB mutation is significantly associated with the RNA expression of many other genes, with 1,818 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNCB-associated genes across cancer lineages are NDUFA4P2, DAD1, and RNA5SP414. Each is linked with SNCB in more than 1 cancer types. Because this analysis shows association rather than direction, both SNCB-to-partner and partner-to-SNCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA4P2 grouped by SNCB-low versus SNCB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNCB→partner) and Y-score (partner→SNCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NDUFA4P2 →	+0.495	+3.821	<.001	.007	3	2
UCEC	DAD1 →	+0.443	+3.491	.004	.002	3	2
UCEC	RNA5SP414 →	+0.598	+2.380	<.001	.002	3	2
COAD	PINCR →	+0.632	+3.798	<.001	.009	3	2
COAD	MYCLP2 →	+0.058	+4.308	<.001	.009	3	2
COAD	LINC00534 →	+0.231	+4.196	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,818 associations by consensus.

NDUFA4P2 by SNCB expression — LUAD

Explore this box plot interactively →