SNCB

Across TCGA pan-cancer cohorts, SNCB RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SNCB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNCB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNCB is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where SNCB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNCB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.543	<.001	10	view →
COAD	All	All	−0.293	<.001	7	view →
LUAD	All	All	+0.155	<.001	6	view →
KICH	Female	All	+0.405	<.001	5	view →
LUSC	Male	All	+0.509	<.001	4	view →
READ	Female	All	−0.508	<.001	4	view →
UCEC	All	III,IV	+0.286	.019	4	view →
BRCA	Female	All	+0.081	<.001	4	view →
CHOL	Female	All	+0.090	.004	2	view →
STAD	Female	III,IV	−1.025	.006	1	view →
THCA	All	IV	−0.070	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SNCB–HNSC

Open the HNSC breakdown →