SNCAIP

Across TCGA patient cohorts, SNCAIP mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNCAIP-associated genes across cancer lineages are JNK_pT183_Y185, Cyclin-B1, and GAPDH. Each is linked with SNCAIP in more than 2 cancer types. Because this analysis shows association rather than direction, both SNCAIP-to-partner and partner-to-SNCAIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SNCAIP-low versus SNCAIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNCAIP→partner) and Y-score (partner→SNCAIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.187	-2.137	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.577	+1.807	<.001	.003	3	3
UCEC	GAPDH →	+0.431	+2.415	.005	.002	3	2
SKCM	MYH11 →	-0.596	-1.473	.003	.003	3	2
SKCM	AR →	-0.092	-1.222	.010	.025	3	2
SKCM	Bcl-xL →	-0.104	-1.058	.012	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

JNK_pT183_Y185 by SNCAIP expression — UCEC

Explore this box plot interactively →