SNCAIP

Across TCGA pan-cancer cohorts, SNCAIP RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SNCAIP data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SNCAIP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNCAIP expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

UVM, KIRC, and KIRP are the cancer types where SNCAIP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.356	0.783	<.001	135	view →
KIRC	OS	Tertile	All	0.738	0.586	<.001	103	view →
KIRP	DFS	Tertile	All	0.773	0.923	.002	45	view →
UCEC	DFS	Median	II,III,IV	0.886	0.755	<.001	42	view →
ESCA	DFS	Median	III,IV	0.604	0.281	<.001	35	view →
LGG	OS	Tertile	All	0.933	0.840	<.001	34	view →
STAD	OS	Quartile	All	0.493	0.702	.001	33	view →
ACC	DFS	Quartile	II,III,IV	0.833	0.168	.001	33	view →
LAML	DFS	Median	All	0.489	0.239	.010	28	view →
PAAD	DFS	Tertile	II,III,IV	0.518	0.322	.002	23	view →
TGCT	DFS	Tertile	All	0.690	0.891	.012	12	view →
KICH	OS	Median	II,III,IV	0.657	0.959	.007	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SNCAIP–UVM (DFS)

Open the UVM breakdown →