SNCA

Across TCGA patient cohorts, SNCA mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNCA-associated genes across cancer lineages are Ku80, BRD4, and cIAP. Each is linked with SNCA in more than 1 cancer types. Because this analysis shows association rather than direction, both SNCA-to-partner and partner-to-SNCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SNCA-low versus SNCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNCA→partner) and Y-score (partner→SNCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.415	+2.820	.004	.036	3	1
UCEC	BRD4 →	+0.459	+2.818	.005	.035	2	1
UCEC	cIAP →	+0.193	+2.833	.022	.035	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Ku80 by SNCA expression — UCEC

Explore this box plot interactively →