SNCA

Across TCGA pan-cancer cohorts, SNCA RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SNCA’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNCA RNA is repressed in tumor relative to normal tissue. In most cancer types SNCA is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and BLCA are the cancer types where SNCA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNCA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.637	<.001	11	view →
LUAD	Female	III,IV	−1.476	<.001	9	view →
BLCA	All	IV	−1.269	<.001	8	view →
KIRC	All	All	−0.479	<.001	8	view →
COAD	All	II,III,IV	−0.957	<.001	7	view →
UCEC	All	III,IV	−2.856	<.001	6	view →
BRCA	All	III,IV	−1.454	<.001	6	view →
STAD	All	All	−0.578	.020	4	view →
READ	Female	All	−2.381	.001	2	view →
LUSC	Male	III,IV	−1.889	<.001	2	view →
HNSC	Female	II,III,IV	−0.852	.015	2	view →
CHOL	Female	All	+0.476	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SNCA–THCA

Open the THCA breakdown →