SNCA

Across TCGA pan-cancer cohorts, SNCA RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SNCA data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher SNCA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNCA expression acts as an unfavorable survival marker, although some lineages such as PAAD and UVM show a favorable association.

STAD, PAAD, and HNSC are the cancer types where SNCA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.418	0.651	.001	78	view →
PAAD	DFS	Tertile	All	0.528	0.264	<.001	63	view →
HNSC	OS	Median	IV	0.649	0.765	.004	57	view →
OV	OS	Median	All	0.650	0.727	.003	54	view →
UVM	OS	Median	II,III,IV	0.824	0.449	.002	42	view →
UCEC	DFS	Median	All	0.580	0.704	.002	36	view →
CHOL	DFS	Median	II,III,IV	0.563	0.104	.001	33	view →
ACC	OS	Quartile	All	1.000	0.737	<.001	30	view →
COAD	DFS	Quartile	All	0.661	0.849	.002	27	view →
BLCA	OS	Median	All	0.530	0.702	<.001	26	view →
DLBC	DFS	Tertile	II,III,IV	1.000	0.211	.004	26	view →
ESCA	OS	Tertile	II,III,IV	0.831	0.553	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SNCA–STAD (OS)

Open the STAD breakdown →