SNCA

Across TCGA cell cohorts, SNCA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,296 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SNCA-associated GO terms across cancer lineages are Dopamine uptake involved in synaptic transmission, Negative regulation of neurotransmitter uptake, and Negative regulation of serotonin uptake. Each is linked with SNCA in more than 19 cancer types. Because this analysis shows association rather than direction, both SNCA-to-partner and partner-to-SNCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dopamine uptake involved in synaptic transmission grouped by SNCA-low versus SNCA-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SNCA→partner) and Y-score (partner→SNCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Dopamine uptake involved in synaptic transmission →	+2.220	+4.689	<.001	<.001	3	20
URINARY_TRACT	Negative regulation of neurotransmitter uptake →	+1.798	+3.562	<.001	<.001	3	19
URINARY_TRACT	Negative regulation of serotonin uptake →	+1.798	+3.562	<.001	<.001	3	19
OESOPHAGUS	Regulation of serotonin uptake →	+1.897	+3.961	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Synaptic transmission, dopaminergic →	+2.246	+5.149	<.001	<.001	3	16
KIDNEY	Positive regulation of inositol phosphate biosynthetic process →	+1.710	+4.224	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,296 associations by consensus.

Dopamine uptake involved in synaptic transmission by SNCA expression — BLOOD_Leukemia

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