SNAPIN

Across TCGA patient cohorts, SNAPIN mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAPIN-associated genes across cancer lineages are RNU4-58P, RNU6-340P, and RN7SKP224. Each is linked with SNAPIN in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAPIN-to-partner and partner-to-SNAPIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by SNAPIN-low versus SNAPIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAPIN→partner) and Y-score (partner→SNAPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.621	+5.133	<.001	.008	3	1
UCEC	RNU6-340P →	+0.630	+6.027	<.001	.002	3	1
UCEC	RN7SKP224 →	+0.321	+5.133	<.001	.008	3	1
UCEC	RPL23AP29 →	+0.244	+4.982	<.001	.009	3	1
UCEC	SERPINB8P1 →	+0.537	+5.551	<.001	.004	3	1
UCEC	RNA5SP371 →	+0.871	+5.133	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

RNU4-58P by SNAPIN expression — UCEC

Explore this box plot interactively →