SNAPIN

Across TCGA pan-cancer cohorts, SNAPIN RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SNAPIN data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SNAPIN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNAPIN expression acts as an unfavorable survival marker, although some lineages such as THCA and OV show a favorable association.

UVM, ACC, and LIHC are the cancer types where SNAPIN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.324	0.683	<.001	117	view →
ACC	DFS	Median	All	0.205	0.670	<.001	72	view →
LIHC	OS	Tertile	All	0.715	0.856	.001	55	view →
KICH	OS	Tertile	II,III,IV	0.506	1.000	.001	52	view →
LGG	OS	Median	All	0.371	0.529	<.001	46	view →
LAML	DFS	Median	All	0.431	0.688	<.001	46	view →
KIRP	DFS	Quartile	IV	0.370	0.888	.024	34	view →
SKCM	OS	Median	All	0.813	0.916	.004	28	view →
THCA	OS	Tertile	III,IV	1.000	0.743	.004	27	view →
KIRC	DFS	Median	IV	0.360	0.662	.002	24	view →
ESCA	OS	Median	III,IV	0.297	0.569	.002	24	view →
OV	DFS	Quartile	IV	0.558	0.289	.019	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SNAPIN–UVM (DFS)

Open the UVM breakdown →