SNAI2

Across TCGA patient cohorts, SNAI2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAI2-associated genes across cancer lineages are 4E-BP1_pT37_T46, INPP4B, and JNK2. Each is linked with SNAI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAI2-to-partner and partner-to-SNAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by SNAI2-low versus SNAI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAI2→partner) and Y-score (partner→SNAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.383	-2.986	.019	.035	3	2
UCEC	INPP4B →	-0.334	-3.169	.018	.018	3	1
UCEC	JNK2 →	+0.202	+2.115	.019	.019	3	1
UCEC	mTOR_pS2448 →	-0.144	-3.156	.027	.018	3	1
UCEC	Notch1 →	+0.143	+3.013	.020	.018	3	1
UCEC	p27_pT198 →	+0.155	+2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

4E-BP1_pT37_T46 by SNAI2 expression — UCEC

Explore this box plot interactively →