SNAI2

Across TCGA pan-cancer cohorts, SNAI2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SNAI2 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SNAI2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNAI2 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LAML show a favorable association.

KIRP, ACC, and STAD are the cancer types where SNAI2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.317	0.768	<.001	119	view →
ACC	OS	Tertile	All	0.628	0.935	<.001	96	view →
STAD	OS	Median	III,IV	0.198	0.517	.001	66	view →
HNSC	DFS	Tertile	All	0.627	0.775	<.001	62	view →
MESO	OS	Tertile	All	0.393	0.698	<.001	57	view →
LGG	DFS	Median	All	0.755	0.909	<.001	52	view →
PAAD	DFS	Quartile	All	0.225	0.487	.002	34	view →
ESCA	DFS	Tertile	All	1.000	0.489	.011	21	view →
BLCA	DFS	Quartile	II,III,IV	0.532	0.655	.025	18	view →
TGCT	DFS	Median	All	0.571	0.772	.010	14	view →
LAML	DFS	Median	All	0.509	0.227	.019	12	view →
OV	DFS	Tertile	II,III,IV	0.484	0.581	.028	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SNAI2–KIRP (OS)

Open the KIRP breakdown →