SNAI2

Across TCGA pan-cancer cohorts, SNAI2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SNAI2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNAI2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNAI2 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

HNSC, KIRP, and LUSC are the cancer types where SNAI2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNAI2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.048	<.001	12	view →
KIRP	Female	All	−2.064	<.001	9	view →
LUSC	Male	All	+2.124	<.001	8	view →
LIHC	Male	II,III,IV	+1.844	<.001	8	view →
KICH	Female	All	−2.397	<.001	6	view →
UCEC	All	All	−2.320	<.001	6	view →
THCA	All	All	−0.519	.001	5	view →
BRCA	Female	All	−0.709	<.001	4	view →
PRAD	All	All	−1.303	<.001	2	view →
PAAD	All	All	+1.200	.011	2	view →
STAD	All	IV	+0.866	.006	1	view →
READ	Female	All	−0.846	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SNAI2–HNSC

Open the HNSC breakdown →