SNAI2

Across TCGA cell cohorts, SNAI2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SNAI2-associated genes across cancer lineages are LUZP4, NOBOX, and MAGEB4. Each is linked with SNAI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAI2-to-partner and partner-to-SNAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LUZP4 grouped by SNAI2-low versus SNAI2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAI2→partner) and Y-score (partner→SNAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LUZP4 →	+0.569	+5.060	<.001	.001	3	1
BLOOD_Leukemia	NOBOX →	+0.054	+4.539	<.001	.007	3	1
BLOOD_Leukemia	MAGEB4 →	+0.046	+4.705	<.001	.003	3	1
BLOOD_Leukemia	OPN5 →	+0.052	+4.409	<.001	.005	3	1
BLOOD_Leukemia	FATE1 →	+0.137	+4.551	<.001	.004	3	1
BLOOD_Leukemia	KRTAP13-4 →	+0.034	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

LUZP4 by SNAI2 expression — BLOOD_Leukemia

Explore this box plot interactively →