SMURF2P1

Across TCGA patient cohorts, SMURF2P1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMURF2P1-associated genes across cancer lineages are OR1D5, MIR3621, and MIR3684. Each is linked with SMURF2P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMURF2P1-to-partner and partner-to-SMURF2P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1D5 grouped by SMURF2P1-low versus SMURF2P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMURF2P1→partner) and Y-score (partner→SMURF2P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR1D5 →	+0.200	+5.484	<.001	.005	3	1
UCEC	MIR3621 →	+1.018	+5.133	<.001	.008	3	1
UCEC	MIR3684 →	+0.985	+5.242	<.001	.007	3	1
UCEC	MIR4319 →	+0.799	+5.358	<.001	.006	3	1
UCEC	OR6K6 →	+0.115	+5.358	<.001	.006	3	1
UCEC	RNA5SP389 →	+2.570	+5.031	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR1D5 by SMURF2P1 expression — UCEC

Explore this box plot interactively →