SMURF2P1

Across TCGA pan-cancer cohorts, SMURF2P1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SMURF2P1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SMURF2P1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMURF2P1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

CESC, LGG, and KIRC are the cancer types where SMURF2P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.670	0.889	<.001	70	view →
LGG	DFS	Tertile	All	0.335	0.538	<.001	34	view →
KIRC	DFS	Tertile	All	0.844	0.685	.004	34	view →
KIRP	OS	Quartile	All	0.668	0.887	.023	32	view →
SKCM	OS	Tertile	All	0.926	0.847	.003	31	view →
LUAD	DFS	Tertile	All	0.604	0.719	.010	25	view →
LUSC	OS	Median	All	0.328	0.488	.003	22	view →
ACC	DFS	Quartile	All	0.108	0.573	.008	12	view →
LAML	DFS	Quartile	All	0.642	0.369	.009	12	view →
STAD	DFS	Tertile	All	0.700	0.544	.018	10	view →
OV	OS	Median	III,IV	0.275	0.355	.007	10	view →
PRAD	DFS	Quartile	All	0.907	0.968	.003	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SMURF2P1–CESC (OS)

Open the CESC breakdown →