SMUG1

Across TCGA patient cohorts, SMUG1 mutation is significantly associated with the RNA expression of many other genes, with 196 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMUG1-associated genes across cancer lineages are OR12D1, OR52J2P, and OR5I1. Each is linked with SMUG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMUG1-to-partner and partner-to-SMUG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D1 grouped by SMUG1-low versus SMUG1-high in LAML.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMUG1→partner) and Y-score (partner→SMUG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	OR12D1 →	+0.117	+5.135	<.001	.007	3	2
LAML	OR52J2P →	+0.077	+5.643	.002	.003	3	2
SKCM	OR5I1 →	+0.287	+7.219	<.001	<.001	3	2
UCEC	MIR8070 →	+0.513	+2.454	.005	.008	3	2
UCEC	RNU6-451P →	+0.685	+2.994	<.001	.003	3	2
UCEC	RNU6-939P →	+0.188	+4.075	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 196 associations by consensus.

OR12D1 by SMUG1 expression — LAML

Explore this box plot interactively →