SMS

Across TCGA patient cohorts, SMS mutation is significantly associated with the RNA expression of many other genes, with 2,380 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMS-associated genes across cancer lineages are PPIAP27, LINC01712, and RNU4-58P. Each is linked with SMS in more than 1 cancer types. Because this analysis shows association rather than direction, both SMS-to-partner and partner-to-SMS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAP27 grouped by SMS-low versus SMS-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMS→partner) and Y-score (partner→SMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPIAP27 →	+0.353	+3.875	<.001	.006	3	2
LUSC	LINC01712 →	+0.084	+4.399	.001	<.001	3	2
UCEC	RNU4-58P →	+0.152	+2.207	.005	.006	3	2
UCEC	CISD3 →	+0.524	+2.354	.001	.003	3	1
UCEC	MYO19 →	+0.462	+2.321	.001	.001	3	1
UCEC	GGNBP2 →	+0.364	+1.958	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,380 associations by consensus.

PPIAP27 by SMS expression — SKCM

Explore this box plot interactively →