SMPD3

Across TCGA patient cohorts, SMPD3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,043 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SMPD3-associated proteins across cancer lineages are SMPD3_S209, SMPD3_S203, and TERF2IP. Each is linked with SMPD3 in more than 8 cancer types. Because this analysis shows association rather than direction, both SMPD3-to-partner and partner-to-SMPD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMPD3 versus SMPD3_S209 in BRCA, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD3→partner) and Y-score (partner→SMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMPD3_S209 →	+2.275	+1.719	<.001	<.001	3	9
UCEC	SMPD3_S203 →	+1.491	+1.356	<.001	<.001	3	7
GBM	TERF2IP →	+0.431	+0.998	<.001	<.001	3	5
BRCA	STARD10 →	+0.682	+0.895	.002	<.001	3	5
BRCA	AP1M2 →	+0.372	+0.776	<.001	.001	3	5
GBM	ICAM1 →	-0.540	-0.611	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,043 associations by consensus.

SMPD3 vs SMPD3_S209 — BRCA

Explore this scatter interactively →