SMPD3

Across TCGA pan-cancer cohorts, SMPD3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SMPD3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMPD3 RNA is repressed in tumor relative to normal tissue. In most cancer types SMPD3 is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where SMPD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMPD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−1.040	<.001	12	view →
THCA	Female	II,III,IV	−0.614	<.001	9	view →
COAD	Female	II,III,IV	−1.131	<.001	8	view →
LIHC	Male	All	−0.924	<.001	8	view →
LUSC	All	All	−0.848	<.001	7	view →
READ	Male	All	−1.989	<.001	6	view →
BRCA	All	All	+0.338	.007	6	view →
KICH	All	All	−1.007	<.001	5	view →
PAAD	Male	All	+2.210	.036	2	view →
ESCA	All	II,III,IV	+0.964	.008	2	view →
LUAD	Female	III,IV	−0.878	.007	2	view →
PRAD	All	All	+0.616	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SMPD3–HNSC

Open the HNSC breakdown →