SMPD3

Across TCGA pan-cancer cohorts, SMPD3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SMPD3 data layer compared with 9 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMPD3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SMPD3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

HNSC, LGG, and UCEC are the cancer types where SMPD3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.749	0.608	.002	59	view →
LGG	OS	Median	All	0.521	0.370	<.001	53	view →
UCEC	DFS	Tertile	All	0.890	0.772	<.001	52	view →
STAD	DFS	Quartile	II,III,IV	0.715	0.555	.012	22	view →
THYM	OS	Median	All	0.967	0.734	.004	16	view →
KIRC	DFS	Tertile	All	0.550	0.730	.010	15	view →
ESCA	OS	Median	All	0.617	1.000	.009	15	view →
CESC	OS	Tertile	All	0.780	0.493	.004	12	view →
LUAD	DFS	Quartile	IV	0.283	0.753	.021	8	view →
KICH	DFS	Tertile	II,III,IV	0.887	0.538	.028	7	view →
SKCM	DFS	Quartile	All	0.680	0.508	.015	7	view →
BRCA	DFS	Median	III,IV	0.916	0.838	.016	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SMPD3–HNSC (DFS)

Open the HNSC breakdown →