SMPD3

Across TCGA patient cohorts, SMPD3 mutation is significantly associated with the RNA expression of many other genes, with 1,875 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPD3-associated genes across cancer lineages are ZWINT, GINS2, and NUDT2. Each is linked with SMPD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMPD3-to-partner and partner-to-SMPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by SMPD3-low versus SMPD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD3→partner) and Y-score (partner→SMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.611	+1.893	<.001	<.001	3	3
UCEC	GINS2 →	+0.688	+1.935	<.001	<.001	3	3
UCEC	NUDT2 →	+0.403	+1.958	.004	.002	3	3
UCEC	GLOD4 →	+0.413	+3.180	<.001	<.001	3	3
UCEC	TIPIN →	+0.415	+1.914	<.001	<.001	3	3
UCEC	CDC6 →	+0.749	+2.191	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,875 associations by consensus.

ZWINT by SMPD3 expression — UCEC

Explore this box plot interactively →