SMPD3

Across TCGA patient cohorts, SMPD3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPD3-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and ARID1A. Each is linked with SMPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPD3-to-partner and partner-to-SMPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SMPD3-low versus SMPD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD3→partner) and Y-score (partner→SMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.249	-1.874	.003	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.148	-1.308	.008	.030	3	2
UCEC	ARID1A →	-0.162	-3.169	.010	.018	3	2
UCEC	TIGAR →	+0.105	+1.901	.039	.001	3	2
UCEC	Cyclin-B1 →	+0.571	+2.906	.002	.001	3	2
STAD	Myosin-IIa_pS1943 →	+0.628	+3.000	.023	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

EGFR_pY1068 by SMPD3 expression — UCEC

Explore this box plot interactively →