SMPD3

Across TCGA cell cohorts, SMPD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,652 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SMPD3-associated GO terms across cancer lineages are Regulation of myoblast fusion, Regulation of syncytium formation by plasma membrane fusion, and Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway. Each is linked with SMPD3 in more than 12 cancer types. Because this analysis shows association rather than direction, both SMPD3-to-partner and partner-to-SMPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by SMPD3-low versus SMPD3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD3→partner) and Y-score (partner→SMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.103	+0.802	<.001	<.001	3	13
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.099	+0.850	.005	<.001	2	12
LUNG_SCLC	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.145	+2.758	<.001	<.001	3	10
OVARY	Regulation of mRNA splicing, via spliceosome →	+0.085	+0.661	<.001	.001	3	10
SOFT_TISSUE	Regulation of RNA splicing →	+0.106	+0.570	<.001	.001	3	10
OESOPHAGUS	Vesicle uncoating →	+0.165	+0.752	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,652 associations by consensus.

Regulation of myoblast fusion by SMPD3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →