SMPD3

Across TCGA cell cohorts, SMPD3 mutation is significantly associated with the RNA expression of many other genes, with 454 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMPD3-associated genes across cancer lineages are IQCF5, OR2M5, and SMCP. Each is linked with SMPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPD3-to-partner and partner-to-SMPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by SMPD3-low versus SMPD3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD3→partner) and Y-score (partner→SMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IQCF5 →	+0.060	+4.977	<.001	.002	3	2
SOFT_TISSUE	OR2M5 →	+0.014	+4.369	<.001	.008	3	1
SOFT_TISSUE	SMCP →	+0.101	+4.369	<.001	.008	3	1
SOFT_TISSUE	FCRL4 →	+0.010	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR51I1 →	+0.486	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4X2 →	+0.013	+4.369	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 454 associations by consensus.

IQCF5 by SMPD3 expression — SOFT_TISSUE

Explore this box plot interactively →