SMOX

Across TCGA patient cohorts, SMOX mutation is significantly associated with the RNA expression of many other genes, with 1,759 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMOX-associated genes across cancer lineages are TRAJ26, NF1P10, and FAM230D. Each is linked with SMOX in more than 2 cancer types. Because this analysis shows association rather than direction, both SMOX-to-partner and partner-to-SMOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ26 grouped by SMOX-low versus SMOX-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMOX→partner) and Y-score (partner→SMOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TRAJ26 →	+1.011	+4.626	<.001	.001	3	3
CESC	NF1P10 →	+0.289	+4.984	<.001	.003	3	2
LUAD	FAM230D →	+0.129	+3.423	<.001	.006	3	2
LUAD	RNU6-975P →	+0.503	+3.841	<.001	.002	3	2
LUAD	RN7SKP259 →	+0.271	+3.946	.006	.003	3	2
UCEC	PSAT1P4 →	+0.123	+1.476	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,759 associations by consensus.

TRAJ26 by SMOX expression — LUSC

Explore this box plot interactively →