SMOX

Across TCGA pan-cancer cohorts, SMOX RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SMOX data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SMOX RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMOX expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

LUAD, LIHC, and UVM are the cancer types where SMOX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.612	0.748	<.001	125	view →
LIHC	OS	Median	All	0.604	0.767	<.001	77	view →
UVM	DFS	Quartile	III,IV	1.000	0.350	<.001	52	view →
UCS	DFS	Median	II,III,IV	0.548	0.177	.001	42	view →
COAD	DFS	Median	All	0.585	0.793	.001	40	view →
LUSC	DFS	Tertile	III,IV	0.353	0.723	<.001	39	view →
PAAD	DFS	Tertile	All	0.251	0.511	.005	35	view →
MESO	OS	Quartile	II,III,IV	0.498	0.749	.007	33	view →
SARC	OS	Tertile	All	0.646	0.849	<.001	27	view →
ACC	DFS	Tertile	All	0.211	0.700	.001	26	view →
SCLC	OS	Median	IV	0.219	0.729	.003	15	view →
KIRP	DFS	Quartile	All	0.418	0.938	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SMOX–LUAD (OS)

Open the LUAD breakdown →